The Mighty Avengers Vol. 1 (2007-2010) #1

Plot

The super-hero Civil War is over, but Iron Man's work is just beginning. As the new head of S.H.I.E.L.D. and creator of the nationwide Initiative program, he's rebuilding the Avengers with a handpicked roster of Earth's mightiest heroes: Wasp, Black Widow, Wonder Man, Sentry, Ares and new team leader Ms. Marvel. A group this powerful should be ready for just about anything — except, perhaps, the return of genocidal killing machine Ultron. The Avengers' insane robotic foe has rebuilt himself yet again, this time in the form of... a beautiful woman!? Then, the team faces an even bigger threat when their outlaw ex-teammate Spider-Woman shows up with evidence that shape-shifting Skrulls have infiltrated Earth. Iron Man faces a harrowing dilemma: Who can he trust when any one of his allies might be an undetectable alien invader? There's no time to figure it out, though, when a bio-weapon transforms New York's populace into Venom-like monsters. Plus: the New Avengers, a time-travel quest and an earth-shaking confrontation with Doctor Doom!

Collecting MIGHTY AVENGERS #1-11.