The Amazing Spider-Man Annual Vol. 1 (1964-2018) #19

Plot

The son of spider slayer cometh! The genius yet goofy progeny of Professor Spencer Smythe decides it's time to redeem the family name by killing Spider-Man once and for all! And Alistair Smythe begins his scheme by determining that the web-slinger is none other than...Mary Jane Watson! What?! Strange but true! The eccentric madman captures Mary Jane and her aunt in a Manhattan restaurant and thinks his triumph is complete! Until the one and only wall-crawler arrives on the scene! Does the novice Alistair realize what he's gotten into? Your friendly neighborhood Spider-Man is going to show him how the big boys play! (mycomicshop.com)