The Amazing Spider-Man Vol. 1 (1963-1998) #200

Plot

Spidey has been zapped with a chemical depressant by Mysterio and lost his powers; Even worse, Aunt May has been murdered, leaving Peter alone in the world; As Spider-Man begins to piece things together, he comes to the realization that the killer he is hunting for is the same burglar who killed his Uncle Ben so many years ago; Powerless yet determined and learning that the burglar has merely captured rather than killed Aunt May, Spidey has a final confrontation with the man who changed his life forever.