The Amazing Spider-Man Vol. 2 (1998-2013) #523

Plot

Spidey is in an underground Hydra bunker battling evil versions of the Avengers when the real Avengers show up to lend a hand; Iron Man and Spidey fly off to stop the launch of a missile full of biological agents that will destroy the most important natural water supply in the Midwest; They are too late and the missile takes off but Spidey hitches a ride; He is able to divert the warhead over the ocean but gets caught in the explosion.